天津大学研究生e-Learning平台

In this work, we fabricated MoS₂ quantum dot@Polyaniline (MoS₂@PANI) nanohybrids and explored them as both photothermal adsorbing agents and radiosensitizers for combined PTT and RT, which has not been investigated up to now. Nanoscaled transition metal dichalcogenides, such as MoS₂and WS₂,have been reported as new photothermal agents for PTT in vitro and in vivo. Moreover, MoS₂ is anticipated to be a very competent candidate for use as radiosensitizers for RT due to its high Z number. The as-prepared MoS₂ quantum dots (MoS₂ QDs) with an average diameter of 5 nm could also produce the strong fluorescence and thus could use as promising and biocompatible probes for in vitro imaging. The obtained MoS₂ QDs core was mixed in the presence of polyvinylpyrrolidone (PVP), sequentially sealed in a PANI shell through in situ polymerization of anline by dispersing the as-grown cores in an acid aniline solution and mildly stiring at room temperature to form MoS₂@PANI. Interestingly, PANI is a promising photothermal agent because of their good in vitro and in vivo biocompatibility, significant photothermal conversion efficiency, and remarkable photostability.The prepared MoS₂@PANI nanohybrid could be extended to use as a contrast agent for both photoaccoustic (PA) and X-ray computed tomography (CT) imaging of tumors due to its high NIR absorption and strong X-ray attenuation. As a consequence, the MoS₂@PANI nanohybrid provides a new possibility in exploring the versatile inorganic-organic nanoplatform for simultaneous biomedical imaging and combined PTT and RT of tumors.