| 内容提要: |
The author reported a concise chemical synthesis of
kalihinol C via a possible biosynthetic intermediate,
“protokalihinol”, which was targeted as a scaffold en
route to antiplasmodial analogs. High stereocontrol of the
kalihinol framework relies on a heterodendralene cascade
to establish the target stereotetrad. Common problems of
regio- and chemoselectivity encountered in the kalihinol
class are explained and solved. |