研究生学术报告预告登记(开题、中期、答辩)

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报告人: 王宇佳
学号: 2015213037
学院: 药物科学与技术学院
报告类型: 第一次学术报告
日期: 21 October 2015
时间: 10:00 AM
地点: 24-406
导师: Jay Siegel
题目: synthesis of indenocorannulenes
内容提要:

Corannulene (C20H10) is the smallest non-planar fragment of C60.1 Because of its bowl-shaped structure, mono-substituted corannulene, if static, is a chiral compound (C1). At room temperature, corannulene undergoes a rapid, dynamic bowl inversion (2 × 105 s-1) through a planar transition state (C2v), which renders it into an achiral compound.2 Energy of activation for the bowl inversion of corannulene has been deduced experimentally as 11.5 kcal/mol.3 However, if two of the peri positions of corannulene are tethered together to form indenocorannulene, the inversion barrier becomes more than double. Therefore, the bowl-to-bowl inversion does not happen at room temperature. Both C-Fand C-Cl activation4,5 methodologies provide fruitful synthesis of chiral indenocorannulene derivatives. (Scheme 1.) C-Cl activation displays a general higher yield and greater functional group tolerance.

 

图片:
登记人: 王宇佳
登记时间: Saturday, 21 April 2018, 6:59 PM