| 内容提要: |
The structurally unique diterpenoid (+)-harringtonolide was first isolated from the seeds of Cephalataxus harringtonia by Buta and co-workers in 1978, and subsequently from the bark of the Chinese species Cephalotaxus hainanensis by Sun et al. in 1979, yet under the name of hainanolide. Hainanolidol, the structural congener of hainanolide was also isolated. The cagelike diterpenoid contains an unusual tropone ring, a compact cis-fused tricyclic ring system carrying seven contiguous stereogenic centers, a bridged lactone, and a tetrahydrofuran ring. (+)-Harringtonolide was shown to inhibit the growth of tobacco and beans and to be antineoplastically and antivirally active. In addition, it was found to have potent cytotoxic activities with an IC50 = 43 nm for KB tumor cells and to cause necrosis under certain conditions. |