| 内容提要: |
Many CYP metabolites are known to be critical in bone development, including retinoic acid, cholesterol, vitamin D, and estrogen. Moreover, the POR knock-out mouse model has shown that POR deletion from bone leads to defects in both skull development and long bone trabecular bone density. This suggests that POR/CYP system is involved in the development and growth of bone 10.
Several human CYPs, namely CYP11A1, CYP17A1, CYP19A1 (aromatase), CYP24A1, and CYP27B1, respectively, were previously shown to be expressed in osteoblasts 11. In mice, Cyp11a1, Cyp39a1, Cyp51 were demonstrated to be expressed in osteoprogenitor cells which are involved in steroid metabolism 12. Currently, the function of CYPs in human bone, especially in osteoblasts, is poorly understood. The effects caused by loss-of-function mutations in human CYP17A1 13 as well as mouse Cyp1 14, Cyp27b1 15 and Cyp11a1 12 suggests that these genes are involved in the development and growth of bone. However, the role of CYPs in bone biology is still unknown. |