| 内容提要: |
Doxorubicin (DOX) is an anthracycline anticancer drug, which can treat a variety of human neoplasms such as leukemias, lymphomas, breast cancer, sarcomas and other malignancies. However the adverse effects of DOX quite limit the using of it in clinical. DOX-induced cardiotoxicity is usually caused by oxidative stress, which was attributed to the rich content of mitochondria in heart tissues. Besides that, promoting the release of pro-inflammatory cytokines can also contribute to DOX-induced cardiotoxicity. It is reported that ginsenoside Rb1 and Rg1 are powerful free radical scavengers and have tissue protection effects by increasing the ratio of Bcl-2 and BAX and preventing the cardiac toxicity of DOX. In addition schisandrin is also reported to inhibit cell apoptosis, reduce reactive oxygen species and decrease LDH leakage. Ginsenoside Rg1 and other ginsenosides have the protection of liver and kidney via interfering with oxidative stress, inflammation and apoptosis. Therefore our report show the possible mechanisms of these three compounds and we will also show the whole experiment design of this project. |