| 内容提要: |
PI3K-AKT is the main signaling pathway involved in cell survival and the proliferative signal in the tumor cells. The serine/threonine AKT, known as protein kinase B, is a pivotal component of cell survival, metabolism, invasion, metastasis, as well as anti-apoptosis and
cell-cycle progression in response to essential cytokines. Yang et al. showed that TRAF6 was found to be a E3 ligase for AKT. And activated AKT can inhibit the apoptosis of tumor cells. However, with the help of the computer aided drug design, we had found that quinine can combine with TRAF6 and inhibit the activation of AKT. So, we
wanted to detect the early apoptosis of the cells after the stimulation of quinine |