| 内容提要: |
In this research, we constructed an innovative multifunctional drug delivery
platform by gadolinium (Gd)-based bovine serum albumin (BSA) hybrid-coated
hollow gold nanoshells (Au@BSA-Gd). The obtained nanoparticles exhibited
excellent photothermal effect andcomputed tomography (CT)/photoacoustic (PA)
activity. Besides, the BSA-bioinspired gadolinium complex endowed the
nanoparticles with an excellent T1 contrast agent for magnetic
resonanceimaging (MRI). In addition, the near-infrared (NIR)
absorbingphototherapeutic agent [indocyanine green (ICG)] was loaded into to perform photodynamic/ photothermal property and near-infrared fluorescence (NIRF)/PA imaging capability. As a result, the well-designed nanocomposites (ICG-Au@BSA-Gd) endow simultaneous photodynamic/photothermal combined cancer therapy and NIRF/PA/CT/MR
quadmodal imaging abilities. |