| 内容提要: |
Studies on triterpene acid type compounds have caught broad attention recently. Triterpene acid type compounds are widely distributed in Chinese traditional medicine (TCM), which is the most common one in terpene. Triterpene acid is one of the triterpene acid type exists in unbound state, which can be divided into tetracyclic triterpene and pentacyclic triterpene, of which pentacyclic triterpenes are most common in TCM. Common triterpenoids can be divided into lupane, oleanane type, Ursane type, cork type and lanostane type triterpene acid. Among them, lanostane belong to the tetracyclic triterpenes. Triterpene acid type compounds have many excellent physiological and pharmacological activities, including antiinflammatory,antiviral, antibacterial and the role of calming the nerves.Literatures also reviewed its immune regulation, regulation of blood sugar, blood pressure lowering and antitumor activity. It is popular especially for the feature of prevention and treatment of tumor with natural components, low toxicity and high efficiency. In vivo and in vitro studies have found many antitumor effects of triterpene acid type components, such as inhibition of cell proliferation, effects of signal transduction, apoptosis, inhibition of the secretion of matrix metalloproteinases and tumor invasion etc.This review introduces antitumor activity of many subtypes of triterpene acid type components including the lupane, oleanane, Ursane, cork and lanostane, and the progress of antitumor mechanism is also reviewed. |