| 内容提要: |
We demonstrated the potential of O2@PFH@HMoSx-HSA/AlPc as a theranostic nanoplatform for fluorescence (FL)/PA/CT multi-modal imaging and NIR laser triggered PTT/Oxy-PDT synergistic therapy. Under the single wavelength NIR laser irradiation (670 nm), photothermal effect induced by HMoSx could produce significant increases in local temperature. Then, the soaring heat, which could reach the boiling point of PFH, markedly accelerated the AlPc and O2 release from O2@PFH@HMoSx-HSA/AlPc and thus promptly activated the Oxy-PDT effect. The smart O2@PFH@HMoSx-HSA/AlPc nanoparticles possessed multiple unique advantages. (1) Oxygen self-enriched property: O2@PFH@HMoSx-HSA/AlPc could carry the oxygen into tumor site, allowing activatable oxygen release in the hypoxic tumor environment to enhance the PDT effect. (2) Stimuli response: AlPc/O2 release and the subsequent Oxy-PDT could be photothermally maneuvered under the single wavelength NIR laser irradiation. (3) Multifunction: O2@PFH@HMoSx-HSA/AlPc could serve as a multifunctional platform to integrate complementary imaging modalities and synergistic PTT/Oxy-PDT therapeutic strategies together. Thus, our O2@PFH@HMoSx-HSA/AlPc would be a promising agent for tumor hypoxia modulation and triple-modality imaging guided PTT/Oxy-PDT synergistic cancer treatment with enhanced tumor inhibition efficacy. |