| 内容提要: |
| In this study, we first successfully demonstrated a folic acid ligand conjugated Lipid-polyaniline hybrid nanoparticle (FA-Lipid-PANI NP) which could simultaneously act as targeted PA and thermal theranostic agent for cancer diagnosis and treatment in living mice. We introduced a method of preparing hybrid PANI nanoparticles combined emeralidine salt (ES) PANI doped by dodecylbenzene sulfonic acid (DBSA) with the phospholipids, which was conceptually distinct from other technologies reported up to the present. In order to further improve the cancer selectivity, folic acid (FA) as the targeting ligand was conjugated on the surface of Lipid-PANI NPs to obtain FA-Lipid-PANI NPs. Hence, the hybrid FA-Lipid-PANI NPs exhibited some unique advantages. (1) Biosafety: FA-Lipid-PANI NP was nontoxic and biodegradable by using the biocompatible lipids as coating agents for intravenous administration. (2) Tumour targeting: FA-Lipid-PANI NPs possesed both passive and active tumor-targeting abilities via enhanced permeability and retention (EPR) effect and folic receptor-mediated transcytosis, respectively. (3) Theranostics: FA-Lipid-PANI NPs could be simultaneously used as PA imaging contrast agents and photothermal agents for tumor theranostics. |
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