| 内容提要: |
The first total syntheses of aflavazole (6)
and 14-hydroxyaflavinine (8), two sterically congested
indole diterpenoids, were accomplished. AlI3-promoted
alkyne Prins cyclization was exploited to construct their
key structural motifs. An electrocyclization-aromatization
sequence assembled the pentasubstituted arene of 6, and a
Stille-Migita coupling furnished the tetrasubstituted olefin
of 8. The benzylic and allylic C-O bonds were reductively
cleaved at the late stage of the syntheses, respectively. |