| 内容提要: |
In this report, I explain three potential mechanism of Yiqi Fumai Lyophilized Injection attenuates doxorubicin-induced toxicity. Doxorubicin (DOX) is one of the most effective antineoplastic drugs, however, its organ toxicity inhibits the clinical utility. This study was aimed at investigating the protective effects of Yiqi Fumai Lyophilized Injection (YQFM) against DOX-induced tissue injury and exploring the mechanisms which mediated by reactive oxygen species (ROS), inflammation and apoptosis. The experiment was as follows: rats were subjected to an intraperitoneal injection (i.p.) of YQFM (0.481 g/kg, i.p.) for 12 days; DOX (5 mg/kg, i.p.) was administered on 4th, 8th and 12th day to get a cumulative dose of 15 mg/kg. Pretreatment of YQFM significantly ameliorated intracellular damage and dysfunction of heart, liver and kidney via decreasing activities of injury indexes. The levels of lipid peroxidation and glutathione depletion were clearly reduced following YQFM pretreatment, meanwhile the activities of glutathione peroxidase, superoxide dismutase, and catalase were elevated. Additionally administering YQFM could mitigate the cardiotoxicity, hepatotoxicity and nephrotoxicity via reducing levels of inflammatory factors and decreasing apoptosis. Accordingly, this study indicated that YQFM attenuated DOX-induced toxicity by ameliorating organ function, decreasing ROS production, preventing excessive inflammation and apoptosis. |